Amyloid Polypeptide Disaggregation Activity of Passion Fruit Seed-Derived Polyphenol Compounds

In an aging society, the prevalence of Alzheimer disease (AD) and type 2 diabetes (T2D) has increased. It is currently hypothesized that these diseases are caused by aggregation amyloid β (Aβ) in brain human islet polypeptide (hIAPP) islets Langerhans, respectively. Therefore, disaggregation existing aggregates a promising approach to prevention treatment both diseases. our previous studies, we found remarkable Aβ hIAPP inhibitory activity polyphenolic compounds containing catechol moieties. Compared reports on their activity, there few compounds. Additionally, findings hIAPP. this study, investigated scirpusin B, compound passion fruit seeds, related Thioflavin T (Th-T) assays transmission electron microscopy (TEM) were performed evaluate Aβ42 activities. The results showed B its activity. structure–activity relationship revealed presence moieties important for This study also polyphenols from seeds have significant against aggregation.